{"id":173532,"date":"2022-01-11T00:00:00","date_gmt":"2022-01-11T00:00:00","guid":{"rendered":"https:\/\/ceotudent.com\/?p=173532"},"modified":"2022-01-16T17:28:01","modified_gmt":"2022-01-16T14:28:01","slug":"what-is-nager-syndrome-rare-inherited-disease","status":"publish","type":"post","link":"https:\/\/ceotudent.com\/en\/what-is-nager-syndrome-rare-inherited-disease","title":{"rendered":"What is Nager Syndrome? Rare Inherited Disease"},"content":{"rendered":"

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Nager’s syndrome; It is a rare inherited disease that was first introduced to the medical literature by Nager and De Reynier in 1948.<\/p>\n

It is a congenital condition that affects the bones and tissues of the face. It also appears to affect the arms and hands, and sometimes the legs and feet, while cheekbones, eye sockets, and chin may not develop properly in early pregnancy. This condition causes a characteristic appearance with downward sloping eyes and a small chin. Nager syndrome is similar to Treacher-Collins syndrome, with additional problems in the arms and hands and often associated with a cleft palate.<\/p>\n

Nager syndrome is distinguished from other forms of acrofacial dysostosis by limb abnormalities, primarily on the thumb side of the hand and forearm, including underdevelopment or absence of the thumb and radius bones in the forearm and abnormal bone fusion in the forearms. Fingers and feet are usually normal. Intelligence is usually not affected. Nager syndrome is typically inherited in an autosomal dominant pattern and is caused by changes (mutations) in the SF3B4 gene.<\/p>\n

Although an individual with Nager syndrome can pass the condition on to their children, many cases occur randomly as a new gene change in the family. This syndrome is typically inherited in an autosomal dominant pattern and is caused by changes in a gene called SF3B4.<\/p>\n

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